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Their seemingly miraculous properties have been praised by tech CEOs, podcaster Joe Rogan, and celebrities such as Gwyneth Paltrow, Jennifer Aniston, and Kim Kardashian, who says her daily regimen changed my life. But many doctors are alarmed by a craze that has thousands of people injecting themselves with substances of dubious origin and whose long-term effects are unknown

Overuse or excessive dosing may increase side effects without enhancing outcomes

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Smith NM, Byard RW, Bourne AJ (1991) Testicular regression syndromea pathological study of 77 cases