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The Continuum Concept, one of the most fundamental principles of physiology, biology, and disease, explains the status of an individual from optimal health to a hidden imbalance, progressing to severe dysfunction, ultimately leading to disease (41)

However, independent human evidence confirming meaningful anti-aging effects is extremely limited

Nearly all the samples contained significant contaminants, including heavy metals, even when the amount of peptide matched what was listed on the label

Western blot analysis quantified protein expression levels, utilizing total protein extracts as well as nuclear and cytoplasmic fractions

Seiwerth et al., 2018)), delaying practical realization of the growth factor healing concept