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Specifically, yeast cells lacking GDH3 exhibited sensitivity to thermal and oxidative stress as well as oxidative stress-dependent accumulation of ROS that led to apoptotic cell death [23]

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In all the five studies, an oral (Delpres study via sublingual route) dose of 1000 g vitamin B 12 was used with the exception of Kuzminskis study, whereby a higher dose of 2000 g was used

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