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As detailed above in retinal degeneration models, recent rodent studies demonstrate that EE housing activates protective pathways in the retina by preventing diabetes-induced VEGF overexpression, a hallmark of early retinal compromise, and by preserving BDNF levels while diminishing inflammation and oxidative damage (Dorfman et al., 2014)

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The scientific papers reviewed for this article involve enzyme systems, cultured cells, rats or mice