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Topical effects Most reported topical effects are mild and local: redness, tingling, dryness, or transient irritation at the application site, typically more common with concentrations above 4%

J Headache Pain 17(1):100 Wei HL, Zhou X, Chen YC et al (2019) Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura

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