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While the exact cause is not fully understood, it is believed to be related to how semaglutide affects digestion and intestinal motility

GLP-1 receptors are present in Sertoli and Leydig cells, which means that these drugs have the potential to directly affect testicular function in addition to improving hormonal balance

Nat Rev Endocrinol 2013;9:1327

typically resolving within 1-2 days of implant placement Expected effects : Skin hyperpigmentation at implant site and systemically (expected pharmacological effect) Melanocytic monitoring : Low rates of new nevi (4% versus 2% placebo in Phase 3)

IUD), or adding in a barrier method (e.g