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18-24 months: Approaching labeled expiration

One insult by itself isnt probably going to do anything

The problem leads to vision loss or pain

Lastly, epithalon plays a significant role in the endocrine system by increasing levels of endogenous hormones that naturally diminish with age, such as melatonin (which helps regulate the sleep cycle), and gonadotropic hormones (FSG, LG, prolactin), which play a role in reproductive functions [8]

That systemic reach is actually an advantage if you're dealing with more than one problem at once

There is work on corticotropin, on luteinizing hormone, and on growth hormone release, which places it loosely in neuroendocrine territory alongside its effects on hormonal balance