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Peroxynitrite is highly toxic to neurons and causes hyper-excitability of the central nervous system, a process known as "kindling." This leads to autonomic nervous system dysfunction (dysautonomia), sensory overload, and severe cognitive deficits

Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine

SGLT2 inhibitors had a similar effect on risk reduction for hospitalization for HF and CV death for those using a GLP-1 (HR = 0.76

Improved metabolic health: Better blood sugar control and reduced insulin resistance

As a clinical pharmacist, I see this as a "Biological Software Update," not a muscle crisis

Prediction of pediatric dose of tirzepatide from the reference adult dose using physiologically based pharmacokinetic modelling