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However, pretreatment with GLP-1 down-regulated MG-induced activation of caspase-3 and the cleavage of PARP in RINm5F cells (Fig

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GLP-1s are contraindicated in individuals with a history of medullary thyroid carcinoma, a family history of such, or in patients with multiple endocrine neoplasia syndrome type 2

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This method enables fine-tuned processing of precursor peptides, achieving high product purity and enzymatic efficiency