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Preclinical and cell culture research has examined exogenous glutathione for its capacity to replenish intracellular GSH pools under oxidative stress conditions, modulating Nrf2/ARE pathway activity and mitochondrial redox balance

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Bridget Somine Glutathione is Essential for Lung Health: This is Why from Lily Mazzarella on Vimeo

doi: 10.1016/j.molcel.2023.06.004 364 ZhouS.HuangH.ChenQ.TanK.ZhuZ.PengY.et al

These enzymes protect cells from oxidative damage, a major contributor to aging and disease

Inhibition of cco-1 is a well-known intervention that, similarly to mrps-5 RNAi, activates the UPR mt and extends lifespan in worms 21