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Using this therapy as a tool to treat PAD in patients without diabetes may be a game-changer in terms of reducing morbidity and mortality. Prospective controlled clinical trials are warranted to examine the current impact of GLP-1RA on non-diabetic PAD patients

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Lin HY, et al

Tirzepatide, the active ingredient in Mounjaro, is a GLP-1 agonist receptor

Tirzepatide augments insulin release in a glucose-dependent manner, reducing the risk of hypoglycemia commonly associated with non-glucose-dependent insulin secretagogues, such as sulfonylureas and meglitinides [19]

108 Later, the FDA added a warning about the risk of anaphylactic shock to the medications label