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First, metabolic regulation occurs through direct modification of metabolic enzymes affecting their activity and stability, as demonstrated in the glycolysis pathway regulation [56]

The range of uses for loop diuretics is broad and includes generalized edema, pulmonary edema, hypertension, heart failure, hypercalcemia, oliguria (diminished urine output), ascites, and anion overload

Haemoglobin assessment involves a full blood count, which measures not only haemoglobin concentration but also red blood cell count, haematocrit, and red cell indices that help distinguish between different causes of elevation

doi:10.1038/s41586-022-05525-z 36