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Bacterial cells, such as lipopolysaccharides (LPS) and peripheral inflammatory mediators enter the brain via BBB, causing neural inflammation, and subsequently induce neuropathological changes, such as synaptic defects, degeneration, abnormal neurons, and brain chemicals discharge which contribute to the development of depressive disorders
Health Topics 2012c
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For gastrointestinal use, it is commonly discussed for gut irritation, gastritis-type symptoms, reflux-type irritation, inflammatory gut symptoms, and mucosal support
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A summary of clinically-significant GLP-1RAs described in this text and their clinical uses are listed in Table 1
