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Under constant exposure, receptors are pulled off the cell surface and become less responsive over time (receptor desensitization). Higher doses maintain more signal against that fade
However, there is a condition called Iron Deficiency Without Anemia (IDWA) of which I discuss in my post at healthunlocked.com/pasoc/po
The one constant is consistency of timing and route for a mechanism that works by gradually shifting cellular metabolism, day-to-day steadiness matters more than any single dose
(2) NNMT catalyzes the N-methylation of nicotinamide using SAM as a methyl donor, consuming both substrates in the process
