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They are not interchangeable with prescription therapy, but they may have a role in a broader mast cell support strategy in selected patients

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doi: 10.1016/j.physbeh.2008.04.018 15 BurmeisterMABrownJDAyalaJEStoffersDASandovalDASeeleyRJet al

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Semaglutide reduces HF symptoms in obesity-associated HFpEF and diminishes major adverse cardiovascular event (MACE) risks and mortality in both HFpEF and HFrEF (Kosiborod et al., 2023, 2024