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Appetite suppression from GLP-1 activation occurs primarily through hypothalamic neurons, particularly in the arcuate nucleus
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Direct Effects on the Optic Nerve: Some research suggests that GLP-1 receptors are present in the optic nerve, raising the possibility that these drugs may directly affect neural tissue in ways that increase vulnerability to ischemia
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If this line of thinking is applied to the mesolimbic GLP-1R activation, it is plausible that while NAc GLP-1R activation is associated with a suppression of the dopamine signal, the VTA GLP-1R reduce reward behavior via another mechanism
Meric-Bernstam F, Lee RJ, Carthon BC, Iliopoulos O, Mier JW, Patel MR, et al
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