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However, the characteristics of the patients included in the clinical trials give some indication

While these mechanisms can explain the protective effect that GLP-1 RA exposure had on the fracture risk of the exposed patients in our study, it is important to consider the fact that the findings mentioned were from studies primarily conducted on patients prescribed GLP-1 RA who had a diagnosis of T2DM, as this is what the drugs were originally FDA-approved to treat

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More significantly, MOTS-c administration shifted the trajectory of age-related metabolic decline, indicating that the peptide's benefits are not limited to preventing dysfunction in young animals but can partially reverse established decline [2]

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