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Although both studies explored the association of TMPRSS6 polymorphisms with DM, finding that rs855791 and rs4820268 were linked to iron metabolism markers and the former showed sex-specific risk differencespossibly due to metabolic, hormonal, and physiological disparities between sexesthey had limitations including uncontrolled ethnic variations, sample constraints, and uninvestigated mechanisms beyond iron metabolism
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As previously mentioned, cortisol stimulates TDO, increasing the conversion of TRP to KYN and shifting metabolism toward neuroactive metabolites
213 amino acid residues) was determined by molecular replacement at 1.9 resolution
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