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The chosen specificity effectively reduced IgG recycling in cells and the IgG plasma half-life in relevant human transgenic mice and NHPs both as a full-length IgG4 and as other monovalent Fab-containing molecules [124]

"This blocks interactions between melanocytes [the skin cells that produce melanin] and keratinocytes [cells that provide skin structure]." By blocking interactions between the two, dark spots, signs of melasma, and post-acne hyperpigmentation become less pigmentated, creating a clearer, more radiant tone

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