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Storage Once reconstituted, retatrutide generally needs to live in the fridge

Semaglutide generally produces greater metabolic improvement, but metformin remains valuable: Much lower cost makes it accessible regardless of insurance Decades of safety data Can be combined with semaglutide for enhanced effect Appropriate first-line option when cost is prohibitive Many providers use both medications, starting metformin for initial treatment and adding semaglutide when additional improvement is needed or when weight loss is a priority

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Wegovy : A higher-dose version of semaglutide, its FDA-approved for obesity and weight management without diabetes

Vomiting, constipation, and injection site reactions rounded out the most frequent adverse events