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We provide researchers with not just the molecules, but also the context necessary for informed study design

Within two weeks, I noticed my range of motion improving and less next-day soreness

If you are designing a study, the takeaway is that the strongest signal is in skin and connective-tissue models, the supporting literature concentrates around the Pickart groups body of work, and effects outside those model systems should be treated as more provisional

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This suggests potential for combination protocols that leverage multiple mechanisms to support cartilage health