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When to Consider Alternative or Combination Approaches If semaglutide response remains poor after 34 months at therapeutic dose (1.5 mg/week), providers may explore alternative GLP-1 agents, tirzepatide (which activates both GIP and GLP-1 receptors), or combination therapy
Adv Ther (2020) 37(10):442745
Can I switch from semaglutide to tirzepatide
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