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This effect is mediated, at least in part, by the suppression of the Toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-B) signaling pathway (Zhai et al., 2025)

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MT-IIs engagement with MC1R facilitates melanogenesis, while its binding to MC4R has shown significant potential in modulating sexual behaviors in females and erections in male study volunteers [13, 14]