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Semaglutide ameliorates Alzheimer's disease and restores oxytocin in APP/PS1 mice and human brain organoid models, Biomedicine & Pharmacotherapy (2024), DOI - 10.1016/j.biopha.2024.117540,

Two large randomized controlled trials EVOKE and EVOKE+ studied whether oral semaglutide could slow the progression of early Alzheimers disease

That reason could be adjusting the dose or tailoring the medication to a specific patient

PMID 28843240

Individuals were excluded if they met any of the following criteria: chronic liver disease other than NAFLD, including alcohol, viral, drug-induced, autoimmune and genetic diseases, liver cirrhosis, or clinical diagnosis of hepatic decompensation (such as oesophageal varices or ascites)

They also performed a mediation analysis to assess the treatment's contribution to the observed changes