It plays a pivotal role in glucose metabolism and appetite regulation through multiple mechanisms: Enhances insulin secretion: GLP-1 stimulates pancreatic -cells to release insulin in a glucose-dependent manner Suppresses glucagon: Reduces hepatic glucose production Delays gastric emptying: Creates prolonged satiety Central nervous system effects: Acts on appetite centers in the brain to reduce hunger and food intake Protects pancreatic -cells: Promotes cell proliferation and inhibits apoptosis GLP-1 Receptor Agonists in Clinical Practice GLP-1 receptor agonists (GLP-1 RAs) are medications designed to mimic the action of endogenous GLP-1 but with enhanced pharmacokinetic properties
RossiOxidative stress and human diseases: origin, link, measurement, mechanisms, and biomarkersCrit Rev Clin Lab Sci, 46 (2009), pp
Multiple compounds targeting the same pathways may cause excessive stimulation or unpredictable interactions
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The deproteinized samples were incubated with necessary reaction components for 30 min at room temperature protected from light