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Additionally, there was no systematic measurement or control for tobacco use, despite evidence indicating that nicotine exerts an effect on GLP-1, which may contribute to reduced feelings of hunger [49]
Related reading on PlexusDx: GLP-1 Drugs, GLP-1 Hormone, What Is GLP-1, GLP-1 What Is
Semaglutide and GLP-1 StatPearls Overview
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However, in most trials, participants received metformin, either as monotherapy or in combination with other agents, except for three trials where participants received no background glucose-lowering therapy after randomisation [26, 40, 49]
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