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Recently, Altimmune reported interim data for its weekly injectable GLP-1/glucagon dual agonist (pemvidutide) in a Phase 2 trial--disappointing levels of discontinuations sent the stock tumbling 55%

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Smaller employers more frequently exclude coverage due to cost concerns and uncertain return on investment

The challenges: GLP-1s can also: Slow gastric emptying, which increases operative risks Cause slower wound healing if nutritional intake is low Lead to muscle loss, which can reduce recovery strength Continue to suppress appetite during a period where nutrition is critical Some surgeons require: A pause before surgery (often 24 weeks) Evidence of stable nutrition A personalised post-operative plan to avoid nausea and ensure adequate protein intake In short, GLP-1s can help, but they must be used mindfully and usually require a pre- and post-surgery strategy with your healthcare provider

This includes: Review of your medical history, current medications, and weight-related symptoms Baseline vitals and lab work to evaluate metabolic function, kidney and liver health, and cardiovascular risk Goal-setting that reflects your real-life priorities whether thats reducing joint pain, improving energy, or qualifying for surgery Youll leave this visit with a clear plan for nutrition, hydration, and movement that fits your lifestyle without unrealistic demands or crash dieting