The average age of the participants was 42 11 years, and there were more men (73.6%) than women
However, because they initially absorb through oral membranes, bypassing the stomach to go straight to the bloodstream, they shouldnt need as high of a dose.6 Research indicates a certain amount of difficulty absorbing peptides through regular digestion, so sublingual absorption could prove superior.7 The only problem is that sublingual delivery mechanisms for semaglutide haven't been tested to establish an effective dose outside of the compounding pharmacy industrys internal publications, which are more marketing materials than clinical research
Clinical trials have demonstrated greater weight loss with these higher doses compared to diabetes-indicated doses, with Wegovy producing average weight reductions of 12-15% of body weight
Understanding what this means requires looking at both the tirzepatide component and the B6 addition separately
PlexusDx recommends establishing a stable, effective tirzepatide dose first before considering adjunctive therapies
Always seek professional advice to rule out underlying pathologies