how long do semaglutide take to work Does GLP-1 Work? Does semaglutide work right away?

doi: 10.1016/j.ejphar.2025.177953

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More concerning from a clinical perspective is the potential for lean mass loss associated with rapid weight reduction

The most common side effects reported were nausea and diarrhea: About half of adults who use GLP-1 agonists reported having experienced nausea, and about one-third of adults who use GLP-1 agonists reported having experienced diarrhea

Despite this, people with type 2 diabetes tend to lose less weight on a GLP-1 than people who don't have the condition, and for reasons that aren't quite clear, says Silvana Obici, MD, chief of the division of endocrinology at Stony Brook Medicine and medical director of the Stony Brook University Hospital Diabetes Center in New York

doi:10.1200/JCO.2026.44.16_suppl.11000 Shah Z, Hundal J, Afridi SS, et al