glp-1 analogs glp-1_analogs [TUSOM Unlock the Potential of GLP-1

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In Japan, during the first 6 months after the launch of sitagliptin, cases of severe hypoglycemia increased when sitagliptin was added onto a sulfonylurea, especially in elderly patients with renal insufficiency [44]

These include a relative or absolute increase in glucagon secretion from alpha cells of the pancreas, elevated serum free fatty-acid concentrations, an impaired incretin effect (e.g., decreased secretion of glucagon-like peptide-1 [GLP-1]), enhanced renal reabsorption of glucose, and dysregulation of appetite control via decreased neurotransmitter response in the brain

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Pierce-Messick, Z

It can cause low energy, cognitive problems, and even mimic dementia