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In theory with ideal, healthy intestinal flora these bacteria will produce a portion of the required B12

Hydroxocobalamin might stay in the body longer

Vitamin B12 deficiency has become common in those subject to alterations in the acidity of the digestive tract, those who follow a vegetarian or vegan diet, and those who frequently undergo antibiotic treatments

Get started In clinical trials of the oral Wegovy (semaglutide) pill, participants taking the medication with diet and exercise achieved average weight loss of about 14%17% over ~64 weeks compared with ~2% with placebo

World Health Organization, NCBI Bookshelf

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