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Specifically, Akkermansia has been shown to alleviate low-grade chronic intestinal inflammation and improve gut barrier function ( Akkermansia can reduce the development of obesity and metabolic syndrome, and is thus considered a candidate for the next-generation probiotic ( Romboutsia has been positively associated with skeletal muscle antioxidant capacity and glucose metabolism ( Romboutsia s trains can restore gut barrier function in type 2 diabetic mice by producing short-chain fatty acids and reducing levels of pro-inflammatory cytokines and lipopolysaccharides ( Clostridium_sensu_stricto_1 group are capable of producing short-chain fatty acids, such as butyrate, which are often reduced during metabolic disturbances including fat accumulation and liver fibrosis ( Clostridium_sensu_stricto_1 and activate functional pathways related to amino acid and short-chain fatty acid biosynthesis ( Clostridium_sensu_stricto_1 e xerts a protective effect against the progression of diabetic kidney disease ( Erysipelatoclostridium and Bacteroides were significantly increased in samples with metabolic disturbances

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