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Senescence is generally regarded as a tumor suppressive process, preventing cancer cell proliferation and suppressing malignant progression
Recent mechanistic work revealed that ferroptosis could inhibite by mTOR, which in turn upregulates the expression of Sterol Regulatory Element Binding Protein 1 (SREBP1), leading to monounsaturated fatty acid (MUFA) production [147]
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Multiple pathways of NAD + synthesis have been identified, which are differentially active in tissues and utilize various molecular precursors to ensure maintenance of NAD + homeostasis and counteract NAD + turnover
Biochem J (2009) 417:113
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