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Molecular mechanisms of autophagy decline during aging

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Studies in Crat knockout mice demonstrated that CrAT deficiency leads to abnormal fuel selection, which results in a perturbation of glucose homeostasis and suggest that deficits in CrAT activity might contribute to diet-induced metabolic inflexibility by exacerbating the Randle glucose-fatty acid cycle 66

Though most CoQ10 is made by the body, levels naturally decline with age and even the highest food sources may not be enough to influence levels adequately

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