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Comparative analysis of two NNMT bisubstrate inhibitors through chemoproteomic studies: uncovering the role of unconventional SAM analogue moiety for improved selectivity

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NICE has issued technology appraisals for semaglutide 2.4 mg (Wegovy) for weight management (TA875) and for tirzepatide (Mounjaro) for managing overweight and obesity , each with defined eligibility criteria