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Here's how the competitive field looks on tolerability bearing in mind that cross-trial comparisons have limitations in trial design, population, and duration: Semaglutide 2.4mg (Wegovy) STEP 1: Nausea: ~44% Vomiting: ~24% Diarrhea: ~30% Discontinuation due to AEs: ~7% Tirzepatide 15mg (Zepbound) SURMOUNT-1: Nausea: ~33% Vomiting: ~12.2% Diarrhea: ~23% Discontinuation due to AEs: ~6.3% Survodutide 4.8mg (Boehringer/Zealand) Phase 2 Obesity: Nausea: ~63.6% Vomiting: ~35.1% Diarrhea: ~19.5% Discontinuation due to AEs: ~28.6% (highest dose)