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Effect of eplontersen on cardiac structure and function in patients with hereditary transthyretin amyloidosis
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The synergy between exogenous MOTS-c and exercise is not merely additive: because MOTS-c mimics one of the molecular consequences of high-intensity exercise (AMPK activation via AICAR accumulation), concurrent exercise training may amplify the peptide's effects on GLUT4 translocation and mitochondrial biogenesis
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Most large-scale trials have had relatively short follow-up periods (typically 2 to 4 years), and the sustained efficacy of these therapies beyond this timeframe has not been fully established
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