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Severe kidney disease can be problematic because kidneys must process detoxification byproducts

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37 The activation of specific membrane receptors triggers the differentiation of nave T cells into effector T cells, also known as T eff cells

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VEGF overexpression is especially critical, as tumor cells use it to drive angiogenesis around them, securing essential oxygen and nutrients for growth and metastasis [195]

Bloodwork can track inflammation markers (e.g., CRP) for efficacy