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As the main substrate of lipid peroxidation released from PL in the cell membrane, AA is a precursor of proinflammatory mediators that can be metabolized by cyclooxygenases (COX), ALOX, and CYP450 monooxygenases to synthesize biologically active inflammatory mediators, such as prostaglandins (PGs) and leukotrienes [91]
J.FrankeS.WendaB.MullerS.Kientsch-EngelR.SteinG.et al (2003)
The evaluation ensures that therapy is tailored safely to the individuals health profile and treatment goals
Conversely, some patients may experience constipation, which can result from the delayed gastric emptying and altered intestinal motility
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