Future prospective controlled studies and large-scale real-world registries with robust confounding control are warranted to confirm these observations and to better inform optimal treatment selection
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They found that treatment cohorts in randomized controlled clinical trials typically report more pronounced effects than controls for the primary outcomes assessed. Best Health Insurance Companies Of 2022 What these studies demonstrate are key differences between effectiveness in less controlled real-world environments than in clinical trial settings
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Tirzepatide in the clinical record Tirzepatide's evidence base sits in the SURMOUNT program SURMOUNT (tirzepatide for weight management, published in The New England Journal of Medicine , 2022) and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024) while the broader class includes GLP-1 receptor agonists such as semaglutide, liraglutide, and dulaglutide, studied in programs like STEP (semaglutide for weight management, NEJM 2021)
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