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Gastroenterology 169 , 277293.e4 (2025)

To address this, they applied a regression-based method (RePACT), which revealed a diabetes-associated epigenetic signature: decreased chromatin accessibility at motifs for HNF1A/B and RFX6, and increased accessibility at motifs for NEUROD1, NFY, and TP53

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For patients who already have diabetic retinopathy or who have struggled with blood sugar control over many years, this is particularly relevant

SLC25A39 has also been named as a candidate gene in Parkinsons disease (PD) pathogenesis 16 in the context of GSH depletion 17,18,19

Compared to those in healthy women, serum bioactive lipid levels are much lower in women with PCOS (147)