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However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

doi: 10.3389/fimmu.2020.01195

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Wearing a helmet when you ride a motorcycle, giving sterile needles to people who use illicit drugs, that's obviously harm reduction

For maximum benefits, should be administered weekly

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