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doi: 10.3390/PH18010132/S1 292 UllahAMunirSBadshahSLKhanNGhaniLPoulsonBGet al

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Below, we summarize novel therapeutic targets and strategies with clinical application potential to provide more options for disease treatment (Table 1)

When muscle drops too much during weight loss, patients may experience: Reduced strength Lower energy Poorer exercise tolerance Increased frailty risk Greater chance of weight regain Less favorable body shape after weight loss Reduced metabolic flexibility Higher risk of functional decline with aging This is one reason the term skinny fat has become common in wellness conversations

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