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Peptide-based approaches have been claimed to induce pigmentation changes that are more rapid and consistent than those reliant on external UV sources

My view is that the pronounced effect of GLP-1 analogues on gastric emptying is not only an important mediator of satiety and reduced food intake but also a likely mechanism responsible for its effect on type 2 diabetes and cardiovascular disease

doi: 10.3389/fendo.2021.721135 (8) Carlessi R, et al

And a positive trial for treatment in humans used intravenous administration, which may result in different bioavailability