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Ran Q, Liang H, Ikeno Y, Qi W, Prolla TA, Roberts LJ, et al

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Several types of allelic variation have been identified within classes, with GSTM1 -null, GSTT1 -null and GSTP1-Ile105/Ile105 conferring impaired catalytic activity

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Given the promising anti-cancer effects of IGF-IR-targeted agents in preclinical models, clinical trials have been initiated to evaluate the efficacy of anti-IGF-IR mAbs (Table 1) [144,145,146,147,148,149,150,151]