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However, native GLP-1 has a very short half-life of approximately two minutes due to rapid degradation by the enzyme dipeptidyl peptidase-4 (DPP-4)
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while subjects with IGT are known to have normal or mild hepatic, but marked peripheral insulin resistance [44]
Presenting the combination as proven
The main early study tested ipamorelin in rat pituitary cells, anesthetized rats, and conscious swine
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