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GLP-1 agonists like semaglutide lower blood sugar through multiple mechanisms, creating significant hypoglycemia risk when combined with insulin

Healthcare providers should conduct a thorough medication review before prescribing tirzepatide, focusing particularly on medications with narrow therapeutic indices that might be affected by delayed gastric emptying

Additionally, individuals experiencing significant changes in their bowel habits should be particularly vigilant

also, WES was found to increase GLP-1 secretion in vivo [18]