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The triple agonist mechanism (GIP, GLP-1, and glucagon receptors) creates unique conditions where the body preferentially burns fat while supporting muscle protein synthesis when adequate protein intake and resistance training are maintained

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However, most of those were non-inferiority studies, thus mainly aiming to demonstrate the safety rather than the effectiveness of these agents over standard glucose-lowering therapies

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For example, reduced caloric intake due to appetite suppression may contribute to tiredness