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Moreover, a prospective cohort study including 18,961 subjects reported in the year 2022 that a 5-year increase in the duration of diabetes resulted in an excess risk of approximately 20% for CVD and stroke [9]

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However, the EMA advises against using liraglutide and semaglutide in individuals with a creatinine clearance below 30 mL/min, which corresponds to CKD stages 4 and 5 or kidney failure