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Oxidative stress and male infertility, a clinical perspective. Human Reproduction Update , vol, 14, no

Kynurenine is predominantly metabolized to the N -methyl-d-aspartate (NMDA) receptor agonist quinolinic acid (QUIN) in the inflammatory state, contributing to the accumulation of glutamate in the extracellular space, leading to changes in network connectivity associated with depression, fatigue and cognitive impairment

Zaffagnini, M., Michelet, L., Massot, V., Trost, P

doi: 10.3390/cancers15010272 6 WangHZhuTYangKXuCZhangZLiuG

Neurobiol Aging 1998

Loss of muscle is a concern with low calorie dieting such as The Omaha Weight Loss Diet and GLP-1 agonist use